No pre-season trip for Benteke

first_img That means he is still waiting to have his medical, scheduled to be held in the UK, and therefore makes flying him halfway around the world to join up with his prospective new team-mates a fruitless exercise. Manager Brendan Rodgers made Benteke his primary summer target to strengthen his forward line but, after initially refusing to meet the buy-out clause, the sale of Raheem Sterling to Manchester City in a £49million deal prompted a shift in thinking. England international Daniel Sturridge made just 18 appearances last season after missing virtually the first five months of the campaign with injury, and is likely to be sidelined until at least September after undergoing surgery on a hip problem, so Rodgers wants a striker who can stand up to the rigours of the Barclays Premier League. He has Benteke’s fellow international Divock Origi, playing his first season in English football after spending last term on loan at Lille, and summer signing from Burnley Danny Ings at his disposal – having decided Mario Balotelli, Rickie Lambert and Fabio Borini are all surplus to requirements – but needed some proven firepower. The club have invested heavily in Hoffenheim’s Brazil international Roberto Firmino, who could cost them up to £29million, but he is not an out-and-out forward and so Rodgers needed to recruit someone else to play as his spearhead. Liverpool have already bought six new players, including England right-back Nathaniel Clyne at a cost of £12.5million, and Benteke’s arrival would push their summer spending to around £80million. Striker Christian Benteke is highly unlikely to join up with Liverpool for any part of their pre-season tour as negotiations continue over his move from Aston Villa. The Reds travel to Adelaide on Saturday for their third match of pre-season preparations and, with no agreement over the finer details of the Belgium international’s transfer, there is little prospect of him flying out in time to make Friday’s game in Malaysia. Liverpool triggered the 24-year-old’s £32.5million release clause on Friday, but Press Association Sport understands negotiations are continuing as the clubs try to reach an arrangement over payment terms. center_img Press Associationlast_img read more

Quinlan says Munster need to be ‘angry every week’

first_imgHe comments after the defeat away to Stade Francais attracted a lot of attention and prompted many to seriously examine where the province were going wrong.Munster conclude their Champions Cup pool fixtures this weekend and then attention turns to the Pro12 – Anthony Foley’s side currently sit fourth in the table in that competition.last_img

Short 1B Icebreaker Advocates Consider Leasing Sharing

first_imgRep. Don Young speaks at an Arctic symposium in Washington, D.C.Nothing illustrates American disinterest in the Arctic as much as the tiny inventory of U.S. icebreakers: One heavy-duty ship, one medium and one down for repair. Alaska leaders and some federal officials say the country can’t assert its national interests, or see the benefits of increased shipping and resource development in the Arctic, without more icebreakers. But some advocates now say, why buy when you can lease?Download AudioCoast Guard Commandant Paul Zukunft sounds a little embarrassed by the state of the icebreaking fleet.“We have eight times the GDP — probably about eight and a half right now — of Russia,” he said. “Russia has a fleet of over 25 ocean-going icebreakers. They’re building six new nuclear icebreaker. And here we are trying to cobble together and maybe reactivate a 37-year-old icebreaker. Because that’s the best we can do.”For years, Alaska’s delegation to Congress has pleaded for money to build a new icebreaker, and they’ve won appropriations of a few million dollars for pre-construction work. But the Coast Guard says it needs six icebreakers, and a single new ship is projected to cost a billion dollars or more, roughly equal to the Coast Guard’s entire capital budget. Alaska Congressman Don Young says next week he’ll offer a bill to promote alternative funding.“This is a problem,” he said at an Arctic symposium in Washington today. “I’ve been trying to get an icebreaker. (Sen.) Lisa Murkowski’s been trying to get an icebreaker. But Congress is not about to appropriate $1 billion, 400 million for an icebreaker. So we have to figure out to get the money either from the Army, the Navy and the Coast Guard …  a collective organization together to build us icebreakers.”Young says the government should seek bids from the private sector to build an icebreaker and lease it to the government, with the expense divvied among several agencies. Young says he knows leasing is not the Coast Guard’s top choice.“Everyone wants to own their own ship. That’s, by the way, one of the worst things we could do. You own a boat, you find out how much money you lose on it,” he said. “So if you’ve got somebody that’s going to lease it to you, and maintains it for you to standard, that’s the way I’d go.”Some Coast Guard leaders, over the years, have questioned whether a leased ship is appropriate for frontline government missions, where the Coast Guard is asserting U.S. sovereignty. Admiral Zukunft, the current Coast Guard boss, says the service can’t do as much with a leased ship.“First and foremost, you need to have some degree of agility,” he said.You may need to operate that platform beyond what it was designed to operate in a given year, based on the mission demands that are being placed upon it.”For any lease-or-buy decision — whether it’s a a house, a car or a ship — a key factor is how long you intend to keep the asset. After a certain point, buying has the advantage. Also, Zukunft says, Congressional budget rules essentially charge an agency the whole cost of the lease in the first year.“So from a business case, a lease option right now, does not provide us an optimal return on investment for a platform that quite honestly we’ve proven that we can maintain these for 35 or 40-plus years,” he said.But, as with houses and cars, if you don’t have the money, buying isn’t really an option. Sen. Lisa Murkowski this week plugged an idea of former lieutenant governor Mead Treadwell. He says the United States could join other countries to provide an icebreaker escort service. As he sees it, with Canada, Finland, China, maybe Korea, and maybe Russia, the U.S. could set up regular trans-polar convoys. Treadwell says it requires thinking of the Arctic as a shared business asset, like a jointly owned canal.“Suppose we told the ships of the world, ‘meet us at a Port Clarence every Wednesday at noon. And there’s an icebreaker heading out to a port in Iceland or a port in Norway,’” Treadwell said. “And you might pay a fee like you pay a fee for a canal.”Treadwell’s concept couldn’t stand in for some of the Coast Guard’s government missions, but Murkowski says, maybe it makes sense to focus on the commercial service first.last_img read more

125 million gift from Microsoft cofounder launches new institute to probe immune

first_imgPaul Allen Sign up for our daily newsletter Get more great content like this delivered right to you! Country Evan Agostini/AP Photo To refine that understanding, “we want to do a very detailed view of the immune system over time,” Bumol says. Researchers with the institute will track the immune function of three groups of people over periods of 5 years. The first group is 4-year-olds, who are starting to receive vaccinations and whose immune system is about to be assailed by all the pathogens they will pick up in school. The other two groups will be healthy adults in their 20s and 30s and older people between 55 and 65. Scientists at the institute will use recently developed techniques such as mass cytometry, which provides a much more detailed profile of cells’ identity and activities than older methods, to try to determine a baseline for the immune system.With these groups for comparison, scientists will then try to ferret out immune differences in people with either of two cancers—multiple myeloma or melanoma—or with the autoimmune illnesses rheumatoid arthritis, ulcerative colitis, and Crohn disease. In the case of rheumatoid arthritis, Bumol says, researchers will study people who are at risk of developing the disease, in hopes of discovering what sets it off. Institute immunologists will have access to clinical data through partnerships with several medical centers.By including leaders from industry who understand drug development and forming partnerships with clinical researchers, the new institute improves its odds of making discoveries that spawn new treatments, says infection biologist Eric Skaar, who heads the Vanderbilt Institute for Infection, Immunology, and Inflammation in Nashville. And that $125 million won’t hurt. “It’s a large commitment [that] is proportional to the magnitude of the problem,” he says. Cellular immunologist Holden Maecker of Stanford University in Palo Alto, California, agrees that the project “is set up well for success.”The new institute’s approach isn’t revolutionary—other collaborations or researchers are using big data to delve into the human immune system, says immunologist Mitchell Kronenberg, president and chief scientific officer of the La Jolla Institute for Immunology in San Diego, California. “I expect them to make a contribution,” he says, “but I think it will be additive.” Country * Afghanistan Aland Islands Albania Algeria Andorra Angola Anguilla Antarctica Antigua and Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia, Plurinational State of Bonaire, Sint Eustatius and Saba Bosnia and Herzegovina Botswana Bouvet Island Brazil British Indian Ocean Territory Brunei Darussalam Bulgaria Burkina Faso Burundi Cambodia Cameroon Canada Cape Verde Cayman Islands Central African Republic Chad Chile China Christmas Island Cocos (Keeling) Islands Colombia Comoros Congo Congo, the Democratic Republic of the Cook Islands Costa Rica Cote d’Ivoire Croatia Cuba Curaçao Cyprus Czech Republic Denmark Djibouti Dominica Dominican Republic Ecuador Egypt El Salvador Equatorial Guinea Eritrea Estonia Ethiopia Falkland Islands (Malvinas) Faroe Islands Fiji Finland France French Guiana French Polynesia French Southern Territories Gabon Gambia Georgia Germany Ghana Gibraltar Greece Greenland Grenada Guadeloupe Guatemala Guernsey Guinea Guinea-Bissau Guyana Haiti Heard Island and McDonald Islands Holy See (Vatican City State) Honduras Hungary Iceland India Indonesia Iran, Islamic Republic of Iraq Ireland Isle of Man Israel Italy Jamaica Japan Jersey Jordan Kazakhstan Kenya Kiribati Korea, Democratic People’s Republic of Korea, Republic of Kuwait Kyrgyzstan Lao People’s Democratic Republic Latvia Lebanon Lesotho Liberia Libyan Arab Jamahiriya Liechtenstein Lithuania Luxembourg Macao Macedonia, the former Yugoslav Republic of Madagascar Malawi Malaysia Maldives Mali Malta Martinique Mauritania Mauritius Mayotte Mexico Moldova, Republic of Monaco Mongolia Montenegro Montserrat Morocco Mozambique Myanmar Namibia Nauru Nepal Netherlands New Caledonia New Zealand Nicaragua Niger Nigeria Niue Norfolk Island Norway Oman Pakistan Palestine Panama Papua New Guinea Paraguay Peru Philippines Pitcairn Poland Portugal Qatar Reunion Romania Russian Federation Rwanda Saint Barthélemy Saint Helena, Ascension and Tristan da Cunha Saint Kitts and Nevis Saint Lucia Saint Martin (French part) Saint Pierre and Miquelon Saint Vincent and the Grenadines Samoa San Marino Sao Tome and Principe Saudi Arabia Senegal Serbia Seychelles Sierra Leone Singapore Sint Maarten (Dutch part) Slovakia Slovenia Solomon Islands Somalia South Africa South Georgia and the South Sandwich Islands South Sudan Spain Sri Lanka Sudan Suriname Svalbard and Jan Mayen Swaziland Sweden Switzerland Syrian Arab Republic Taiwan Tajikistan Tanzania, United Republic of Thailand Timor-Leste Togo Tokelau Tonga Trinidad and Tobago Tunisia Turkey Turkmenistan Turks and Caicos Islands Tuvalu Uganda Ukraine United Arab Emirates United Kingdom United States Uruguay Uzbekistan Vanuatu Venezuela, Bolivarian Republic of Vietnam Virgin Islands, British Wallis and Futuna Western Sahara Yemen Zambia Zimbabwe Emailcenter_img $125 million gift from Microsoft co-founder launches new institute to probe immune system Immunology is the latest field that will benefit from a hefty sum donated by Microsoft co-founder Paul Allen. The newly launched Allen Institute for Immunology, planned before the philanthropist died in October from complications of non-Hodgkin lymphoma, will attempt to better define what’s normal for the immune system and why it falters in cancer and autoimmune diseases.The institute, which will be announced today at a press conference, will eventually hire about 70 researchers, who will work at the Seattle, Washington, location shared by Allen institutes focused on cell biology and the brain. Their new sibling starts with a nest egg of $125 million from Allen, but it could receive more money from his estate. The immunology institute will differ from the other Allen institutes because “we are going to be really dedicated to understanding disease mechanisms and translational opportunities,” says Executive Director Thomas Bumol, a former senior vice-president at Lilly Research Laboratories.With the recent explosion in immune-based therapies such as checkpoint inhibitors for treating cancer, it might seem that scientists have the immune system figured out. But these drugs aren’t the norm, Bumol says. “The successes are great but, as everyone knows, failure is the predominant result in drug discovery.” A prime reason for these stumbles, he says, is “a lack of understanding of the complexity of the immune system.” By Mitch LeslieDec. 12, 2018 , 10:50 AM Click to view the privacy policy. Required fields are indicated by an asterisk (*)last_img read more