Lab study supports idea of ‘cytokine storm’ in H5N1 flu

first_img See also: Nov 16, 2005 (CIDRAP News) – A recent laboratory study has produced more evidence that infection of human lung cells with the H5N1 avian influenza virus leads to intense inflammation similar to what was seen in victims of the 1918 Spanish flu pandemic. The H5N1 viruses were “more potent inducers” of cytokines and chemokines—chemical messengers that trigger inflammation—than H1N1 viruses were, says the report by a team led by J.S.M. Peiris of the University of Hong Kong. A flood of inflammation-triggering chemicals released by the immune systems has been referred to as a “cytokine storm.” Autopsies of H5N1 avian flu victims in Vietnam and elsewhere have revealed lungs choked with debris from the excessive inflammation triggered by the virus. Similar severe lung damage was frequently reported in victims of the 1918 pandemic, which disproportionately killed people with the strongest immune systems—young, healthy adults. The Hong Kong researchers sought to test their hypothesis that the H5N1 virus’s ability to trigger a flood of cytokines may contribute to the unusually severe disease it causes in humans. They used H5N1 viruses isolated from a patient who died of the infection in Hong Kong in 1997 and from two Vietnamese patients who were infected in 2004, plus an ordinary H1N1 virus isolated in Hong Kong in 1998. Chan MCW, Cheung CY, Chui WH, et al. Proinflamatory cytokine responses induced by influenza A(H5N1) viruses in primary human alveolar and bronchial epithelial cells. Respir Res 2005 (published online Nov 11) [Abstract] Laboratory cultures of human alveolar cells and bronchial epithelial cells were exposed to these viruses. Using real-time polymerase chain reaction (RT-PCR), the researchers assessed the levels of various cytokines and chemokines at several time intervals after infection. “We have found that infection with H5N1 viruses led to the production of 10 times higher levels of cytokines from human cells than normal human flu viruses,” said Peiris, as quoted Nov 12 in The Standard, a Chinese business newspaper.center_img Researchers from Hong Kong report that lung cells growing in a laboratory responded much more intensely to the H5N1 virus than to an ordinary flu virus, even though the viruses reproduced at about the same rate, according to the report published online by Respiratory Research. They found that all the H5N1 viruses caused cells to secrete significantly higher levels of IP-10 (interferon-gamma-inducible protein 10), interferon beta, a type of T cell known as RANTES, and interleukin-6 than the H1N1 virus did. In addition, the 2004 versions of H5N1 caused cells to release more IP-10 at 6 hours than the 1997 version did. Oct 11 CIDRAP News story “Experts cite differences between H5N1 and ordinary flu” The different cytokine responses are not explained by different viral growth rates, because all three virus subtypes replicated with similar efficiency, the article says. “The cellular mechanisms underlying this differential cytokine hyper-induction by H5N1 viruses are presently poorly understood,” it states. The report says previous research has shown that patients with H5N1 disease have higher levels of IP-10 and other chemokines in their blood than do people infected with ordinary flu, a finding that parallels the present laboratory findings. In addition, the article says that studies of recombinant flu viruses carrying genes from the 1918 pandemic virus showed that the recombinant viruses were highly lethal and induced high levels of macrophage-derived chemokines in mice. However, it is not yet clear whether the increased chemokine levels were due to “hyper-induction” of the chemokines or just rapid growth of the virus.last_img read more

Batesville Schools Sports Rescheduled Events

first_imgE.I.A.C. Wrestling Meet . . . At South Dearborn.Monday Night, January 27    Wrestling begins at 4:30 PM.Boys’ Freshman  Tournament. . .  At Connersville High School Gymnasium Monday Night January 27th.Game 1            East Central vs. Lawrenceburg  6:00 PM.Game 2            Connersville vs. Rushville  7:15 PM.Tuesday Night January 28th.Game 3            Batesville vs. Franklin County  6:00 PM.Game 4            Greensburg vs. South Dearborn  7:15 PM.Wednesday Night January 29th .Game 5            Winner Game 1 vs. Winner Game 2  6:00 PM.Game 6            Winner Game 3 vs. Winner Game 4  7:15 PM.Saturday Morning February 1st.Girls Championship Game beginning at 10:00 AM.Boys Championship Game beginning at 11:30 AM.Girls’ Freshman (C) Tournament . . . At East Central  for two rounds.Monday Night , January 27th  (Main Gym).Game 1  Franklin County vs Batesville    6:00 PM.Game 2  Greensburg vs South Dearborn    7:15 PM.Tuesday Night, January 28th (Aux Gym).Game 3    East Central vs winner game 1        6:00 PM.Game 4    Rushville vs Winner Game 2        7:15 PM.Championship game will be played at Connersville, February 1st, 10:00 AM.Girls Varsity and JV Basketball . . .  At Greensburg Tuesday, January 28JV starts at 6:00 PM* Cancel the South Ripley game that was scheduled for that evening.Boys Varsity and JV Basketball . . . At Connersville, Tuesday, February 4.JV starts at 6:00 PM.7th & 8th Girls Basketball at Columbus Central Tournament . . . Not being rescheduled.Submitted by Batesville AD Mark Ferguson.last_img read more

Madison man gets the maximum sentence for Cross Plains burglaries

first_imgVersailles, In. — A Madison man has been sentenced for his role in a series of burglaries in the Cross Plains area.Christian Stewart, 23, was sentenced to the maximum, 42 years, by Judge Jeffrey Sharp after being found guilty as charged of conspiracy to commit burglary while armed with a deadly weapon.Stewart was convicted following a four-day jury trial in December of 2018.Court documents say Stewart and his younger brother, and his girlfriend committed the crimes during the morning and early afternoon of May 16, 2017.  At both scenes, the burglars were extremely destructive and left the buildings completely ransacked.During the Sentencing Hearing, Ripley County Chief Deputy Prosecutor Shane Tucker argued for the maximum sentence. Tucker urged the Court to take into consideration Stewart’s numerous prior convictions and probation violations including a previous burglary in Jefferson County that he was on parole for while he committed these crimes.Ripley County Prosecutor Ric Hertel said, “We are very pleased with the outcome of this case and hope that this sentence can help bring some closure to the victims of these terrible crimes.  The Defendant’s criminal conduct combined with his extensive criminal history and apprehensible behavior in the jail warranted the maximum sentence.”last_img read more

Toshiba To Build Second Production Facility For SCiB Batteries In Japan

first_imgToshiba SCiB are specific batteries that occupy their own niche.Toshiba announced that it anticipates strong future demand for SCiB lithium-ion batteries and decided to build a second production facility in Yokohama.If you were wondering whether or not this means SCiB has a big future in EVs we should cool the enthusiasm, as the investment will be just 16.2 billion yen (about $143 million). That probably doesn’t translate to anything above a few GWhs annually, if even that.Construction will start in July 2019, but operation is two years from now in October 2020.See Also Author Liberty Access TechnologiesPosted on October 22, 2018Categories Electric Vehicle News Toshiba Claims To Achieve Breakthrough In Ultra Fast-Charge Battery The first facility of Toshiba Infrastructure Systems & Solutions Corporation (TISS) is in Kashiwazaki.The SCiB cells are ready for ultra-fast charging in minutes, last for thousands for cycles and operates in a wide range of temperatures, but the drawback is weight (one of the heaviest lithium-ion cells) and probably price.“The SCiB delivers long life operation, rapid charging, high input and output power and a large effective capacity. It operates across a wide temperature range and is very safe. Since its introduction in 2008, its versatility and reliability have won the battery application in electric and hybrid electric vehicles, the drive systems of railroad cars, and energy storage systems in substations.Anticipating strong future demand for SCiB, Toshiba has decided to build an additional production plant in Toshiba’s Yokohama Complex. The facility will also serve as a production technology development center, positioning TISS to respond positively to future expansion of the lithium-ion rechargeable battery market.”Over the past years, Toshiba developed a new titanium niobium oxide – TiNb2O7 (TNO) composite anode, which could enable it to produce better SCiB batteries than the first generation (LTO anode).Source: Toshiba via Green Car Congress Toshiba Claims Battery Breakthrough: 6 Minute Ultra Rapid Recharge Year-Long Electric Bus Test Reveals A CO2 Reduction Of 60% Source: Electric Vehicle Newslast_img read more